Endocrine Abstracts

Introduction: There has been a joint transition clinic in our tertiary centre for over 10 years. We have recently undertaken a questionnaire based review of this service.Methodology: The questionnaire comprised two components: what the young adults understood about their condition and the medications they were currently taking using both a written response and a score of 0–10 for how confident they felt in this. They were also asked to complete a co...

Introduction: The 1 μg low dose short Synacthen tests (LDSST) and the glucagon stimulation tests (GST) have been suggested to be safer alternatives to the insulin induced hypoglycaemia stress test. The aim of this study was to compare the peak plasma cortisol concentration in response to a LDSST followed 60 min later by a GST in children undergoing investigation for short stature.Methods: We retrospectively studied 38 patients (19 female, 19 male) w...

Background: Several devices are available for the administration of recombinant GH. A prospective study was undertaken to look at those attributes of GH delivery device most important to patients when making their choice.Objectives: i) To understand which features of a GH device are considered most important to patients when choosing a device. ii) Comparison of patient’s device preferences at start of GH treatment and after 2 years of treatment. iii...

Cushing’s syndrome (CS) is a rare but severe disease associated with an increased mortality especially due to cardiovascular diseases, and associated with various systemic complications, including hypertension, glucose intolerance or diabetes mellitus, dyslipidemia and coagulopathy. Few studies have systematically evaluated the mortality of CS in a large and worldwide population of CS. The MISSION study is a retrospective study aimed at assessing the mortality in a large ...

Early events in activated by adrenaline (10−6 M) and phenylephrine (10−5M) single hepatocytes of rat have been investigated by quantitative image microfluorometry and microspectrofluorometry. Membrane potential-sensitive cationic DiOC2(3) and anionic SqSC4 probes have been used for image analysis and transmenbrane potential (Δψp) estimation in real-time studies. Fluorescence spectra resulting from the accumulati...

Objective: Nonalcoholic steatohepatitis (NASH) is a metabolic disease characterized by liver steatosis. There is a correlation between liver steatosis and metabolic hormone dysregulation. Subfatin and asprosin are two important metabolic components of adipose tissue and play a role in carbohydrate metabolism, insulin resistance, and glucose regulation. Therefore, the primary aims of this study were to determine how serum and salivary subfatin and asprosin levels change simulta...

Menopause is a physiological condition associated with an important change in the hormonal status, an adverse lipid profile and cardiovascular risk. Apolipoproteins are proteins that bind to lipids to transport them. Apolipoprotein intestine synthesis is regulated principally by the fat content of the diet, while in the liver by dietary composition, hormones, alcohol intake and lipid lowering drugs. Are they changed due to aging? Do they interfere in the hormonal changes?<...

Introduction: The hypothalomo-pituitary response to the loss of ovarian function due to ageing is an increase in GnRH induced gonadothropic activity: FSH. It is thought that the pituitary gives maximum endogenous stimulation leading to FSH levels above the ovarian threshold to develop follicular growth and it is a matter of debate whether exogenous FSH (r-FSH) will or will not improve ovarian response. In intrauterine insemination (IUI) treatment r-FSH is used to induce multif...

Introduction: With IVF stimulation a premature pituitary LH surge can ruin the whole procedure. Traditionally prevention of this event is done by administering a GnRH antagonist against endogenous hypothalamic GnRH. The obvious consequence is low LH levels, one of the two gonadotrophines usually not given for ovarian stimulation since for adequate action FSH suffices. However there are indications that LH levels may render too low, in particular in older women. The aim of this...

Clinical case: A 51 year-old caucasian woman was admitted in the emergency room of our hospital with psicomotor agitation and confusion after four days of a profuse watery diarrhea, with 5 stools per day, abdominal cramps and vomiting. She started 500 mg of aspirin on her own initiative. Her medical profile included a type 2 diabetes treated with metformin 850 mg/12 hours and glyburide 7.5 mg/day, and hypertension treated with enalapril 20 mg/day. No renal imparement was docum...